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Hydrocodone, also known as dihydrocodeinone, is a semi-synthetic opioid synthesized from codeine, one of the opioid alkaloids found in the opium poppy.
Molar mass: 299.368 g/mol Boiling point: 461.4 °C CAS ID: 125-29-1
Trade name: Zohydro ER, Hysingla ER PubChem CID: 5284569
Hydrocodone is usually combined with at least one or more active ingredients and then sold because it is not legal to sell it in its pure form. Its usage as a recreational drug increased significantly in the recent past and now the new rules will make it harder to get. While it is illegal to sell hydrocodone drugs without a prescription, a number of online Hydrocodone stores have emerged that sell the drug without asking for a prescription.
Knowing that its usage is highly controlled and there are severe consequences of its sale unless, under the given regulations, the operations of many such online companies are illegal in their nature. Hydrocodone has been declared a Class A drug, which means that possession of it without a prescription would be dealt with in the most serious manner possible.
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Hydrocodone is used to relieve severe pain. Again, hydrocodone is only used to treat people who are expected to need medication to relieve severe pain around-the-clock for a long time and who cannot be treated with other medications or treatments. More-so hydrocodone extended-release (long-acting) capsules or extended-release tablets should not be used to treat pain that can be controlled by medication that is taken as needed. Hydrocodone is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.
This monograph only includes information about the use of hydrocodone alone. If you are taking a hydrocodone combination product, be sure to read information about all the ingredients in the hydrocodone-combination monograph and ask your doctor or pharmacist for more information. Buy Hydrocodone Online | Buy Hydrocodone | Hydrocodone for Sale
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How Is Hydrocodone Taken?
Hydrocodone comes as an extended-release (long-acting) capsule and an extended-release (long-acting) tablet to take by mouth. The extended-release capsule is usually taken once every 12 hours. The extended-release tablet is usually taken once daily.
Take hydrocodone at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take hydrocodone exactly as directed by your doctor.
Swallow the extended-release capsules or extended-release tablets one at a time with plenty of water. Swallow each capsule or tablet as soon as you put it in your mouth. Do not pre-soak, wet, or lick the extended-release tablets before you put them in your mouth.
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Your doctor will probably start you on a low dose of hydrocodone and may gradually increase your dose, not more than once every 3 to 7 days if needed to control your pain. After you take hydrocodone for a period of time, your body may become used to the medication. If this happens, your doctor may increase your dose of hydrocodone or may prescribe a different medication to help control your pain. Talk to your doctor about how you are feeling during your treatment with hydrocodone. Hydrocodone for sale
Do not stop taking hydrocodone without talking to your doctor. If you suddenly stop taking hydrocodone, you may experience withdrawal symptoms such as restlessness, teary eyes, runny nose, yawning, sweating, chills, hair standing on end, muscle pain, widened pupils (black circles in the middle of the eyes), irritability, anxiety, back or joint pain, weakness, stomach cramps, difficulty falling asleep or staying asleep, nausea, loss of appetite, vomiting, diarrhea, fast breathing, or fast heartbeat. Your doctor will probably decrease your dose gradually. Buy Hydrocodone Online | Buy Hydrocodone | Hydrocodone for Sale
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Effects Of Hydrocodone
- Short-term effects.
In the short-term, the effects of hydrocodone are primarily to modify pain signaling in the central nervous system through interaction with your body’s numerous opioid receptors. As it is a pain reliever, hydrocodone does not work to decrease the source of the pain but rather to change the user’s perception of the pain. This feeling is very sought-after, especially from those dealing with pain that is high in intensity or long in duration.
Other short-term, desirable effects of hydrocodone include:
- Increased sense of well-being.
- Feeling sleepy or lethargic
- Reduced worry and stress.
It’s important to keep in mind that this is a prescription medication, so doctors prescribe it for patients who are experiencing some type of pain, possibly chronic, and looking for relief.
Hydrocodone brings the much-desired relief and, as a side-effect for some, a pleasurable high that interacts with the brain’s reward circuitry. Both effects help to explain why it is easy to become addicted to or dependent on hydrocodone and other opiate drugs, even in situations where initial use was done according to prescribed parameters. Buy Hydrocodone Online | Buy Hydrocodone | Hydrocodone for Sale
Long-term Effects of Hydrocodone
Despite the problems it creates, those locked in a cycle of compulsive drug use continue to seek out and abuse the drug in question.
Addiction may be one of the most dangerous long-term effects of hydrocodone use. Hydrocodone is an opiate, or narcotic, similar to codeine, heroin, and morphine. These kinds of substances are particularly risky because you can become addicted even when you are taking them as recommended by your doctor.
Repeated use of hydrocodone frequently leads to tolerance, so you will need to take more of the drug in order to get the same effect as your body becomes adjusted to the dose or frequency. Tolerance can develop remarkably quickly with these medications, becoming noticeable within a few doses taken, in some cases.
Tolerance can easily lead to addiction. Addiction entails problematic, compulsive drug use that negatively impacts multiple areas of your life. Despite the problems it creates, those locked in a cycle of compulsive drug use continue to seek out and abuse the drug in question.
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Long-term effects of hydrocodone use can include a broad range of physical problems—from acetaminophen toxicity and liver damage to sensorineural hearing loss. Some of the most damaging results of being addicted to hydrocodone, however, may be the adverse effects on your personal life.
Drug addiction can: Wreak havoc on relationships. Cause difficulties with job performance. Lead to mental health problems.
In the above cases, someone with opiate addiction will commit more time, effort, and resources to obtain and use the desired drug. This will leave fewer resources to manage the other facets of life and can be devastating to those that love that person. However, it is possible to recover. Learn how to help a hydrocodone addict. Buy Hydrocodone Online | Buy Hydrocodone | Hydrocodone for Sale
At high doses or in sensitive patients, hydrocodone may produce dose-related respiratory depression by acting directly on the brain stem respiratory center. Hydrocodone also affects the center that controls the respiratory rhythm and may produce irregular and periodic breathing.
Head Injury And Increased Intracranial Pressure
The respiratory depressant effects of narcotics and their capacity to elevate cerebrospinal fluid pressure may be markedly exaggerated in the presence of head injury, other intracranial lesions or a pre-existing increase in intracranial pressure. Furthermore, narcotics produce adverse reactions that may obscure the clinical course of patients with head injuries. Buy Hydrocodone Online | Buy Hydrocodone | Hydrocodone for Sale
Acute Abdominal Conditions
The administration of narcotics may obscure the diagnosis or clinical course of patients with acute abdominal conditions.
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Special Risk Patients
As with any narcotic analgesic agent, NORCO® should be used with caution in elderly or debilitated patients and those with severe impairment of hepatic or renal function, hypothyroidism, Addison’s disease, prostatic hypertrophy or urethral stricture. The usual precautions should be observed and the possibility of respiratory depression should be kept in mind.
Hydrocodone suppresses the cough reflex; as with all narcotics, caution should be exercised when NORCO® is used postoperatively and in patients with pulmonary disease.
In patients with severe hepatic or renal disease, the effects of therapy should be monitored with serial liver and/or renal function tests.
Carcinogenesis, Mutagenesis, Impairment of Fertility
No adequate studies have been conducted in animals to determine whether hydrocodone or acetaminophen have a potential for carcinogenesis, mutagenesis, or impairment of fertility.
Pregnancy Category C
There are no adequate and well-controlled studies in pregnant women. NORCO® should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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Babies born to mothers who have been taking opioids regularly prior to delivery will be physically dependent. The withdrawal signs include irritability and excessive crying, tremors, hyperactive reflexes, increased respiratory rate, increased stools, sneezing, yawning, vomiting and fever. The intensity of the syndrome does not always correlate with the duration of maternal opioid use or dose. There is no consensus on the best method of managing
Labor And Delivery
As with all narcotics, administration of this product to the mother shortly before delivery may result in some degree of respiratory depression in the newborn, especially if higher doses are. Buy Hydrocodone Online | Buy Hydrocodone | Hydrocodone for Sale
Acetaminophen is excreted in breast milk in small amounts, but the significance of its effects on nursing infants is not known. It is not known whether hydrocodone is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from hydrocodone and acetaminophen, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
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Safety and effectiveness in pediatric patients have not been established.
Clinical studies of hydrocodone bitartrate 5 mg and acetaminophen 500 mg did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious. Usually starting at the low end of the dosing range, reflecting the greater frequency of decreased; hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
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Hydrocodone and the major metabolites of acetaminophen are known to be substantially excreted by the kidney. Thus the risk of toxic reactions may be greater in patients with impaired renal function due to; the accumulation of the parent compound and/or metabolites in the plasma. Because elderly patients are more likely to have decreased renal function; care should be taken in dose selection, and it may be useful to monitor renal function.
Hydrocodone may cause confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of hydrocodone tablets and observed closely.
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Following an acute overdosage, toxicity may result from hydrocodone or acetaminophen.
Signs And Symptoms
Serious overdose with hydrocodone is characterized by; respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis). Extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity. Cold and clammy skin, sometimes bradycardia as well as hypotension. In severe overdosage, apnea, circulatory collapse, cardiac arrest, and death may occur. Buy hydrocodone online – buy hydrocodone – Hydrocodone for sale – hydrocodone online
In acetaminophen overdosage: dose-dependent, potentially fatal hepatic necrosis is the most serious adverse effect. Renal tubular necrosis, hypoglycemic coma, and thrombocytopenia may also occur.
Early symptoms following a potentially hepatotoxic overdose may include; nausea, vomiting, diaphoresis and general malaise. Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion. Hydrocodone for sale
In adults, hepatic toxicity has rarely been reported with; acute overdoses of less than 10 grams or fatalities with less than 15 grams. Buy Hydrocodone Online | Buy Hydrocodone | Hydrocodone for Sale
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A single or multiple overdoses with hydrocodone and acetaminophen is a potentially lethal polydrug overdose. Consultation with a regional poison control center is recommended. Hydrocodone for sale
Immediate treatment includes support of cardiorespiratory function and measures to reduce drug absorption. Vomiting should be induced mechanically, or with syrup of ipecac, if the patient is alert (adequate pharyngeal and laryngeal reflexes). Oral activated charcoal (1 g/kg) should follow gastric emptying.
The first dose should be accompanied by an appropriate cathartic. If repeated doses are used, the cathartic might be included with alternate doses as required. Hypotension is usually hypovolemic and should respond to fluids. Vasopressors and other supportive measures should be employed as indicated. A cuffed endotracheal tube should be inserted before gastric lavage of the unconscious patient. When necessary, to provide assisted respiration. Hydrocodone for sale
Meticulous attention should be given to maintaining adequate pulmonary ventilation. In severe cases of intoxication, peritoneal dialysis, or preferably hemodialysis may be considered. If hypoprothrombinemia occurs due to acetaminophen overdose, vitamin K should be administered intravenously. Hydrocodone for sale
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Naloxone, a narcotic antagonist, can reverse respiratory depression and coma associated with opioid overdose. Naloxone hydrochloride 0.4 mg to 2 mg is given parenterally. Since the duration of action of hydrocodone may exceed that of the naloxone. The patient should be kept under continuous surveillance. While repeated doses of the antagonist should be administered as needed to maintain adequate respiration. Buy hydrocodone online – buy hydrocodone – hydrocodone for sale – hydrocodone online
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If the dose of acetaminophen may have exceeded 140 mg/kg, acetylcysteine should be administered as early as possible. Serum acetaminophen levels should be obtained since levels four or more hours following ingestion help predict acetaminophen toxicity.
Do not await acetaminophen assay results before initiating treatment. Hepatic enzymes should be obtained initially and repeated at 24- hour intervals. Buy Hydrocodone Online | Buy Hydrocodone | Hydrocodone for Sale
Methemoglobinemia over 30% should be treated with methylene blue by slow intravenous administration. The toxic dose for adults for acetaminophen is 10 g.
NORCO® should not be administered to patients who have previously exhibited hypersensitivity to hydrocodone or acetaminophen.
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